New Bioactive Diterpenoid from Euphorbia decipiens

نویسندگان

  • Viqar Uddin Ahmad
  • Hidayat Hussain
  • Javid Hussain
  • Amir Reza Jassbi
  • Ishfaq A. Bukhari
  • Amsha Yasin
  • M. Iqbal Choudhary
چکیده

One new diterpene ester with a tricyclic lathyrane-or myrsinol-type skeleton has been isolated fromEuphorbia decipiensBoiss. &Buhse. In addition to one new, the known constituents -amyrin, -amyrin acetate, methyl (2,4-dihydroxy-3-formyl-6-methoxy) phenyl ketone (2), and 1,1-bis (2,6-dihydroxy-3-acetyl-4-methoxyphenyl)methane (3) have been isolated from the same source. The structure elucidation of the isolated compounds was based primarily on 1D and 2D-NMR analysis, including COSY, HMQC, HMBC and NOESY correlations. Compound 1 showed inhibitory activity against prolyl endopeptidase, and also analgesic activity.

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تاریخ انتشار 2002